MUTATIONS IN THE TETA(B) GENE THAT CAUSE A CHANGE IN SUBSTRATE-SPECIFICITY OF THE TETRACYCLINE EFFLUX PUMP

Authors
GUAY GG TUCKMAN M ROTHSTEIN DM
Citation
Gg. Guay et al., MUTATIONS IN THE TETA(B) GENE THAT CAUSE A CHANGE IN SUBSTRATE-SPECIFICITY OF THE TETRACYCLINE EFFLUX PUMP, Antimicrobial agents and chemotherapy, 38(4), 1994, pp. 857-860
Citations number
29
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
4
Year of publication
1994
Pages
857 - 860
Database
ISI
SICI code
0066-4804(1994)38:4<857:MITTGT>2.0.ZU;2-T
Abstract
The tetA(B) gene from transposon Tn10 fails to mediate resistance to t he novel tetracycline analog 9-(dimethylglycylamido)minocycline (DMG-M ino) (P. E. Sum, V. J. Lee, R. T. Testa, J. J. Hlavka, G. A. Ellestad, J. D. Bloom, Y. Gluzman, and F. P. Tally, J. Med. Chem. 37:184-188,19 94; R. T. Testa, P. Petersen, N. V. Jacobus, P. E. Sum, V. J. Lee, and F. P. Tally, Antimicrob. Agents Chemother. 37:2270-2277, 1993). Mutat ions in either of two codons of tetA(B) that resulted in increased res istance to DMG-Mino also caused diminished resistance to tetracycline, identifying amino acid residues critical for the recognition of tetra cycline.