PENETRATION OF CIPROFLOXACIN INTO BRONCHIAL-SECRETIONS FROM MECHANICALLY VENTILATED PATIENTS WITH NOSOCIMIAL BRONCHOPNEUMONIA

The aim of the study was to evaluate the penetration of ciprofloxacin into bronchial secretions from mechanically ventilated patients with n osocomial bronchopneumonia. For this purpose, in each patient studied, simultaneous serial blood and bronchial secretion samples were obtain ed over a 12-h period on days 2 and 4. Eight patients were included in the study. Ciprofloxacin was given at a dose of 200 mg over 30 min by using an automatic pump. Ciprofloxacin was measured by high-performan ce liquid chromatography. Peak levels of drug in serum were 2.95 +/- 1 mg/liter on day 2 and 2.43 +/- 0.7 mg/liter on day 4. Peak and trough levels in bronchial secretions were 0.95 +/- 0.51 and 0.21 +/- 0.12 m g/liter, respectively, on day 2 and 0.76 +/- 0.17 and 0.18 +/- 0.14 mg /liter, respectively, on day 4. The ratios of peak concentrations in b ronchial secretions/serum were 0.32 +/- 0.11 and 0.33 +/- 0.06 on days 2 and 4, respectively. The ratios of the area under the concentration -time curve from 0 to 12 h (AUC0-12) for bronchial secretions/those fo r serum were 0.66 +/- 0.40 and 0.55 +/- 0.30 on days 2 and 4, respecti vely. A significant positive correlation was found on day 4 between th e AUC0-12 for serum and the AUC0-12 for bronchial secretions. No signi ficant correlations were found between peak values in serum and bronch ial secretions.