STRUCTURE AND POLYMORPHISM OF THE MOUSE MYELIN OLIGODENDROCYTE GLYCOPROTEIN GENE/

We have isolated and characterized genomic clones containing the mouse myelin/oligodendrocyte glycoprotein (MOG) gene. It spans a region of 12.5 kb and consists of eight exons. Its exon-intron structure differs from that of classical MHC-class I genes, with which it is linked in the mouse genome. Nucleotide sequencing of the 5' flanking region reve als that it contains several putative protein-binding sites, some of t hem in common with other myelin gene promoters. One intragenic polymor phism has been identified: it consists of a GA repeat, defining at lea st three alleles in mouse inbred strains, and is easily detectable usi ng the polymerase chain reaction method. (C) 1994 Academic Press, Inc.