THE GENES ENCODING ALPHA-2(IX) COLLAGEN (COL9A2) MAP TO HUMAN-CHROMOSOME 1P32.3-P-33 AND MOUSE CHROMOSOME-4

We have determined the chromosomal locations of the human and murine g enes coding for alpha 2(IX) collagen, a polypeptide subunit of the het erotrimeric type M collagen molecule. COL9A2 was mapped to human chrom osome 1p32.3-p33 using fluorescence in situ hybridization. A single-st rand conformational polymorphism within the murine Col9a2 gene was use d to map this locus to mouse chromosome 4. We also present new sequenc e data, which completes the coding information for the human alpha 2(I X) chain and revises the sequence for the chicken alpha 2(IX) chain. T his permits comparison of the carboxyl-terminal (NC1) domains of the a lpha 1(IX), alpha 2(IX), and alpha 3(IX) chains across several species . (C) 1994 Academic Press, Inc.