LOCALIZATION OF THE HUMAN GENES ENCODING THE 2 SUBUNITS OF GENERAL TRANSCRIPTION FACTOR TFIIE

Authors
PURRELLO M DIPIETRO C RAPISARDA A MOTTA S PAVONE L GRZESCHIK KH SICHEL G
Citation
M. Purrello et al., LOCALIZATION OF THE HUMAN GENES ENCODING THE 2 SUBUNITS OF GENERAL TRANSCRIPTION FACTOR TFIIE, Genomics, 23(1), 1994, pp. 253-255
Citations number
11
Categorie Soggetti
Genetics & Heredity
Journal title
Genomics → ACNP
ISSN journal
08887543
Volume
23
Issue
1
Year of publication
1994
Pages
253 - 255
Database
ISI
SICI code
0888-7543(1994)23:1<253:LOTHGE>2.0.ZU;2-S
Abstract
TFIIE is a general transcription factor for class II genes composed of two types of subunits, a large one of 56 kDa and a small of 34 kDa. B y Southern analysis at high and at low stringency of a panel of mouse/ human hybrid cell lines and by in situ chromosomal hybridization, we h ave demonstrated that both polypeptides are encoded by genes that are single copy in the human genome and are localized at 3q13-q21 and at 8 p12, respectively. A TaqI RFLP (heterozygosity index of 0.07) was dete cted at the locus for the 56-kDa subunit. (C) 1994 Academic Press, inc .