CLONING AND CHROMOSOME LOCALIZATION OF THE MOUSE EWS GENE

The human EWS gene encodes a putative RNA binding protein. As a result of acquired chromosome rearrangement, the N-terminal portion of the E WS protein is fused to the DNA binding domain of either FLI-1 or ERG i n the Ewing family of tumors and to the DNA binding domain of ATF1 in malignant melanoma of soft parts. We have determined the cDNA sequence of the mouse Ews gene. Its nucleotide sequence and its translation pr oduct demonstrate 93 and 98% homology with the human EWS cDNA and prot ein, respectively. The murine Ews locus lies within a conserved synten y segment between human chromosome 22q12 and mouse chromosome 11A1-A3. (C) 1994 Academic Press, Inc.