ACTION OF TESTOSTERONE ON THE ANTI-MULLERIAN ACTIVITY OF THE CHICK EMBRYONIC TESTIS ASSAYED IN-VIVO BY ORGANOTYPIC GRAFTING

The implantation of embryonic testis grafts into female chick embryos induces the regression of their Mullerian ducts (MDs) in a certain num ber of cases. The treatment of either the grafts or the grafted female s with testosterone propionate (TP) results in a significant increase in the number of MD regressions observed. Our data are interpretable i n terms of a direct activation by TP of the anti-Mullerian activity of the embryonic testis. We discuss a possible mechanism accounting for the synergistic action of testosterone and anti-Mullerian hormone.