Approximately 10% to 15% of adults have gallstones, resulting in more
than 600,000 cholecystectomies being performed annually in the United
States.(35) It is not surprising, therefore, that biliary disease is a
major consideration in the patient with acute abdominal pain. The int
ernist, the surgeon, and the radiologist all play important roles in t
he assessment of the patient with pain of suspected biliary origin. Cl
inical differentiation of colic of gallbladder origin versus that of b
ile duct origin can be difficult for even the most astute clinician. A
lthough there is no substitute for skillful physical diagnosis, the ra
diologist is often the central player in the evaluation of acute bilia
ry disease. This article focuses on three specific areas of importance
to the radiologist: (1) the diagnostic approach to acute biliary dise
ase; (2) imaging of specific clinical entities; and (3) the relationsh
ip between imaging findings and the use of new therapeutic modalities.