Sa. Ross et al., THE PRESENCE OF TUMOR-NECROSIS-FACTOR IN CSF AND PLASMA AFTER SEVERE HEAD-INJURY, British journal of neurosurgery, 8(4), 1994, pp. 419-425
In a cohort of victims of traumatic brain injury, 18 out of 50 patient
s had a plasma tumour necrosis factor (TNF) concentration above 2 pg/m
l within 24 h ofinjury (mean 12.19, SD 45.96 pg/ml). Twenty-six had CS
F samples available of which 17 demonstrated TNF concentrations above
1 pg/ml (mean 3.98, SD 3.61 pg/ml). We conclude that traumatized brain
parenchyma is a significant source of TNF activity and implicate the
cytokine in cellular metabolic derangements following head injury.