Py. Brichon et al., COMPARISON OF EPIDURAL ANALGESIA AND CRYOANALGESIA IN THORACIC-SURGERY, European journal of cardio-thoracic surgery, 8(9), 1994, pp. 482-486
A prospective study was carried out in 120 patients undergoing electiv
e thoracotomy for parenchymal disease. Patients were randomized into t
hree groups: A (control group), B (epidural analgesia), C (freezing of
intercostal nerves). Subjective pain relief was assessed on a linear
visual analog scale. Analgesic requirements were evaluated during the
12 days following surgery, or until discharge if earlier. The vital ca
pacity (VC) and forced expiratory volume in 1 s (FEV1) were measured o
n the day before operation and on the 1st, 2nd, 3rd and 7th postoperat
ive days (POD). Subjective pain relief was significantly better in Gro
up B in comparison with Group A (P < 0.05) or C (P < 0.05). Group C ha
d the lowest score on the 11th and 12th POD but differences were not s
tatistically significant. Requirements for intravenous analgesics were
lower in Group B than in the control group (P < 0.05) during the firs
t 3 POD, and in group C than in the control group the day of operation
(P < 0.05). Oral analgesic requirements, when compared with controls,
were lower in group B during the first 5 POD, and lower in group C on
the 3rd and the 4th POD (P < 0.05). Cryoanalgesia led to a slight but
not significant increase in VC and FEV1. Epidural analgesia led to a
significant increase when compared with controls in FEV1 during the fi
rst 3 POD, and in FVC on the 7th POD (P < 0.05). It is concluded that
epidural analgesia led to the best pain relief and restoration of pulm
onary function after thoracotomy. Cryoanalgesia seemed to be effective
for pain relief, but a few days later than the former.