IGF-II PRODUCING HEPATIC FIBROSARCOMA ASSOCIATED WITH HYPOGLYCEMIA

A 67-year-old male was admitted with the complaint of weakness at hung er early in the morning, when blood glucose was less than 40 mg/dl. Th e abdominal ultrasonogram and computerized tomogram demonstrated a hug e tumor in the right liver lobe. Hypoglycemia disappeared after transc atheter arterial embolization. Then hepatic lobectomy was performed. T he tumor was histologically shown to be a fibrosarcoma. Insulin-like g rowth factor-II was intensely stained in the Golgi area of the tumor c ells, suggesting its role in the mechanism of hypoglycemia.