Nh. Harley et Es. Robbins, A BIOKINETIC MODEL FOR RN-222 GAS-DISTRIBUTION AND ALPHA-DOSE IN HUMANS FOLLOWING INGESTION, Environment international, 20(5), 1994, pp. 605-610
A biokinetic model for absorption and distribution of 222Rn in the bod
y following ingestion in drinking water was developed. The rate parame
ters for the model are derived from historical human data reported in
experiments of Harley et al. (1958) and Hursh et al. (1965). The bioki
netic model fits the human data of Hursh et al. well for whole body re
tention following ingestion of 222Rn in water on an empty stomach. The
equivalent dose to stem cells for stomach and colon cancer is estimat
ed to be 1.6 x 10(-9) Sv B(q-1). The model calculations yield 4 and 3
calculated stomach and colon cancers from continuous intake of water a
t the estimated U.S. average of 5.5 B(q) L-1.