DIPRIVAN(R) - EFFICIENT CONCENTRATIONS IN RELATION TO PHYSIOLOGICAL-PARAMETERS AND ASSOCIATED DRUGS

According to the literature there is a large inter-individual variabil ity, with blood concentrations often ranging from 1 to 3-fold. These v ariations between patients reduce the value of recommended concentrati ons. In practice it is more important to titrate the dose according to the clinical response (or lack of response), rather than to blindly f ollow the various dosage regimens proposed and, with which it is theor etically possible to rapidly reach and then maintain the desired propo fol concentration. In practice, what is the point of carefully maintai ning a propofol concentration of 3.5 mug . mL-1 (theoretical maintenan ce level for an average patient), if the latter (failing to comply wit h the usual range of concentrations) needs a propofol level of 6 mug . mL? In practice, we must titrate!