LEUPROLIDE ACETATE DEPOT FOR THE TREATMENT OF UTERINE LEIOMYOMAS - CHANGES IN BONE-DENSITY, UTERINE VOLUME AND UTERINE VASCULAR RESISTIVE INDEX

This study measured the changes in uterine volume, uterine vascular re sistive index and lumbar vertebral bone density before and after a six -month course of leuprolide acetate depot in women with uterine leiomy omas. All Mine patients studied were black. The high baseline bone den sity of black women may provide a greater scope for the use of gonadot ropin agonists as compared to women in the general population. A signi ficant reduction in uterine volume was achieved in the patients with l euprolide therapy. Uterine vascular resistive indices were not altered consistently following leuprolide therapy in women with leiomyomas.