A FAMILY OF NOVEL MACROCYCLIC LACTONES, THE SACCHAROCARCINS PRODUCED BY SACCHAROTHRIX AEROCOLONIGENES SUBSP ANTIBIOTICA .2. PHYSICOCHEMICALPROPERTIES AND STRUCTURE DETERMINATION

Six novel tetronic acid analogs were isolated from the fermentation br oth of the actinomycete Saccharothris aerocolongenes subsp. antibiotic a SCC1886. The structures of these saccharocarcins were determined by their spectral data, and chemical degradation. All six compounds are d erived from two modified tetronic acid homologs which differ from othe r tetronic acids bq having an ethyl or propyl side chain at C-23 and a methyl group at C-16. They are all characterized by a novel sugar-ami de at C-17.