PYRALOMICINS, NOVEL ANTIBIOTICS FROM MICROTETRASPORA-SPIRALIS .4. ABSOLUTE-CONFIGURATION

Authors
KAWAMURA N NAKAMURA H SAWA R TAKAHASHI Y SAWA T NAGANAWA H TAKEUCHI T
Citation
N. Kawamura et al., PYRALOMICINS, NOVEL ANTIBIOTICS FROM MICROTETRASPORA-SPIRALIS .4. ABSOLUTE-CONFIGURATION, Journal of antibiotics, 50(2), 1997, pp. 147-149
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
2
Year of publication
1997
Pages
147 - 149
Database
ISI
SICI code
0021-8820(1997)50:2<147:PNAFM.>2.0.ZU;2-I
Abstract
The absolute configurations of pyralomicin 1a and pyralomicin 2a were determined by X-ray crystallographic analyses of crystalline 7'-O-p-br omobenzoylpyralomicin 1a and 2'-O-p-bromobenzoylpyralomicin 2a derived from pyralomicin 1a and pyralomicin 2a using anomalous scattering of the bromine atom. The absolute configurations of pyralomicins 1b-1d an d 2b-2c were suggested to be the same as pyralomicin 1a and pyralomici n 2a, respectively, by comparing the circular dichroism spectra.