THE 1ST ISOLATED ANTINEOPLASTIC RU(IV) COMPLEX - SYNTHESIS AND STRUCTURE OF -CYCLOHEXANEDIAMINOTETRAACETATE)RU]CENTER-DOT-2H2O

Authors
VILAPLANA RA GONZALEZVILCHEZ F GUTIERREZPUEBLA E RUIZVALERO C
Citation
Ra. Vilaplana et al., THE 1ST ISOLATED ANTINEOPLASTIC RU(IV) COMPLEX - SYNTHESIS AND STRUCTURE OF -CYCLOHEXANEDIAMINOTETRAACETATE)RU]CENTER-DOT-2H2O, Inorganica Chimica Acta, 224(1-2), 1994, pp. 15-18
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Inorganica Chimica Acta → ACNP
ISSN journal
00201693
Volume
224
Issue
1-2
Year of publication
1994
Pages
15 - 18
Database
ISI
SICI code
0020-1693(1994)224:1-2<15:T1IARC>2.0.ZU;2-E
Abstract
Treatment of ruthenium(III) chloride with solid cyclohexanediaminetetr aacetic acid (H4cdta) affords the water soluble complex [Ru(H2cdta)Cl2 ].2H2O (1), the first isolated Ru4+ compound showing cytostatic activi ty. Complex 1 has been characterized by X-ray diffraction, electronic spectroscopy and magnetic studies. The molecular structure indicates t hat the chelating ligand acts a tetradentate, showing two free carboxy lic groups. The octahedral coordination around the metal ion is comple ted by two chlorine atoms.