The gene encoding the penton base of human adenovirus (Ad) type 3 has
been sequenced. The resulting amino-acid sequence has an Arg-Gly-Asp (
RGD) motif located near its middle in a hydrophilic region. The same m
otif is found in serotypes 2, 5 and 12. This sequence was found [Wickh
am et al., Cell 73 (1993) 309-319] to be involved in the internalisati
on of Ad2 through an interaction with some specific integrins.