THE PENTON BASE OF HUMAN ADENOVIRUS TYPE-3 HAS THE RGD MOTIF

Authors
CUZANGE A CHROBOCZEK J JACROT B
Citation
A. Cuzange et al., THE PENTON BASE OF HUMAN ADENOVIRUS TYPE-3 HAS THE RGD MOTIF, Gene, 146(2), 1994, pp. 257-259
Citations number
8
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
146
Issue
2
Year of publication
1994
Pages
257 - 259
Database
ISI
SICI code
0378-1119(1994)146:2<257:TPBOHA>2.0.ZU;2-E
Abstract
The gene encoding the penton base of human adenovirus (Ad) type 3 has been sequenced. The resulting amino-acid sequence has an Arg-Gly-Asp ( RGD) motif located near its middle in a hydrophilic region. The same m otif is found in serotypes 2, 5 and 12. This sequence was found [Wickh am et al., Cell 73 (1993) 309-319] to be involved in the internalisati on of Ad2 through an interaction with some specific integrins.