SYNTHESIS AND ANTIVIRAL STUDY OF ACYCLIC ANALOGS OF 3'-AZIDO, 3'-AMINO, AND 3'-FLUORO-3'-DEOXYTHYMIDINE, AND OF HEPT ANALOGS

Authors
TRINH MC FLORENT JC GRIERSON DS MONNERET C
Citation
Mc. Trinh et al., SYNTHESIS AND ANTIVIRAL STUDY OF ACYCLIC ANALOGS OF 3'-AZIDO, 3'-AMINO, AND 3'-FLUORO-3'-DEOXYTHYMIDINE, AND OF HEPT ANALOGS, Synthesis, (9), 1994, pp. 939-943
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
9
Year of publication
1994
Pages
939 - 943
Database
ISI
SICI code
0039-7881(1994):9<939:SAASOA>2.0.ZU;2-N
Abstract
Several new acyclonucleosides have been synthesized from racemic epich lorhydrin or epifluorhydrin. This involves epoxide opening followed by chain elongation with iodomethyl phenyl sulfide and subsequent coupli ng of the phenylthioacetal with thymine. Deprotection afforded the tit le compounds 6, 8 and 18, whereas introduction of a phenylthio group a t C-6 led to the three HEFT analogs, 13, 19, and 24.