STIMULATED HUMAN GASTRIC TUMOR-CELLS (HGT) FAIL TO SYNTHESIZE EICOSANOIDS

Authors
DENIZOT Y ESSAADY D SIMON A DELAGE C NAJID A
Citation
Y. Denizot et al., STIMULATED HUMAN GASTRIC TUMOR-CELLS (HGT) FAIL TO SYNTHESIZE EICOSANOIDS, Cancer letters, 84(2), 1994, pp. 183-187
Citations number
30
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
84
Issue
2
Year of publication
1994
Pages
183 - 187
Database
ISI
SICI code
0304-3835(1994)84:2<183:SHGT(F>2.0.ZU;2-D
Abstract
HGT cells are a human gastric tumor cell line, Preliminary data have s hown that HGT cells incorporate exogenous arachidonic acid (AA) in the ir membrane lipids. However, we found that HCT cells are unable to pro duce significant amounts of AA metabolites after stimulation with calc ium ionophore A23187. Furthermore, no lipoxygenase activity was detect ed in crude HCT cell extracts by employing an assay monitoring the in vitro utilization of linoleic acid. The meaning of these results is di scussed in respect of the role of eicosanoids during cell proliferatio n.