HYPOCRELLIN, FROM HYPOCRELLA BAMBUASE, IS PHOTOTOXIC TO HUMAN-IMMUNODEFICIENCY-VIRUS

Authors
HUDSON JB ZHOU J CHEN J HARRIS L YIP L TOWERS GHN
Citation
Jb. Hudson et al., HYPOCRELLIN, FROM HYPOCRELLA BAMBUASE, IS PHOTOTOXIC TO HUMAN-IMMUNODEFICIENCY-VIRUS, Photochemistry and photobiology, 60(3), 1994, pp. 253-255
Citations number
13
Categorie Soggetti
Biophysics,Biology
Journal title
Photochemistry and photobiology → ACNP
ISSN journal
00318655
Volume
60
Issue
3
Year of publication
1994
Pages
253 - 255
Database
ISI
SICI code
0031-8655(1994)60:3<253:HFHBIP>2.0.ZU;2-A
Abstract
Hypocrellin, a photodynamic perylene quinonoid isolated from the Chine se medicinal fungus Hypocrella bambuase, was evaluated for antiviral a ctivity against the human immunodeficiency virus (HIV-1). Hypocrellin was phototoxic to HIV-1, almost as good as the structurally similar pl ant pigment hypericin, and like hypericin its activity required visibl e light. In contrast peroxyhypocrellin had little or no effect on the virus.