Hypoglossal nerve (cranial nerve XII) palsy is uncommon. Damage to thi
s nerve produces characteristic clinical manifestations, of which unil
ateral atrophy of the tongue musculature is the most important. When t
hese features are recognized, the radiologist, armed with knowledge of
the normal anatomy of the area, can focus on each segment of the nerv
e in search of a cause. The hypoglossal nerve is divided into five seg
ments: the medullary, cisternal, skull base. nasopharyngeal/oropharyng
eal carotid space, and sublingual segments. Because each segment is us
ually affected by different disorders, localizing a lesion to a partic
ular segment allows the radiologist to narrow the differential diagnos
is. In this way, the most efficient imaging strategy for evaluation of
the symptoms can be developed. Both computed tomography and magnetic
resonance imaging are useful in assessing dysfunction of the hypogloss
al nerve; the choice depends on the status of the patient and the pref
erence of the radiologist.