THYMOSTIMULIN EFFECT ON THE IMMUNE-RESPONSE IN NEOPLASTIC PATIENTS SUBMITTED TO SURGICAL-TREATMENT

We selected the data from performance status, disease state, skin test s, circulating lymphocytes and relative subsets, serum immunoglobulin classes to evaluate the immune response in 29 neoplastic patients trea ted with surgery and undergoing Thymostimulin administration during lo ng term follow-up. Moderate drug intolerance was observed in 3 patient s. After treatment lymphocyte count increase (41% mean increase) in 61 .5% of cases; CD3, CD4, CD8, CD16 respectively 95-74-8782% of cases; i mmunoglobulin classes in about 90% of cases. A clear-cut improvement o f Karnofsky's index was observed in 34.6% of cases, worsening in 11.5% . A manifest improvement in the delayed hypersensitivity skin test res ulted in 36% of cases. Most patients (85%) have shown signs of complet e disease remission. Disease progression was observed only in 3 patien ts. There were no infections during this study.