ISOLATION AND STRUCTURE ELUCIDATION OF PERTHAMIDE-B, A NOVEL PEPTIDE FROM THE SPONGE THEONELLA SP

Authors
GULAVITA NK POMPONI SA WRIGHT AE YARWOOD D SILLS MA
Citation
Nk. Gulavita et al., ISOLATION AND STRUCTURE ELUCIDATION OF PERTHAMIDE-B, A NOVEL PEPTIDE FROM THE SPONGE THEONELLA SP, Tetrahedron letters, 35(37), 1994, pp. 6815-6818
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
37
Year of publication
1994
Pages
6815 - 6818
Database
ISI
SICI code
0040-4039(1994)35:37<6815:IASEOP>2.0.ZU;2-O
Abstract
A sponge of the genus Theonella collected off Perth, Australia, contai ned a cyclic octapeptide. perthamide B, which weakly inhibited the bin ding of [I-125]IL-1 beta to intact EL4.6.1 cells with an IC50 of 27.6 mu M. The inhibition of binding could however, not be separated from t he cytotoxic effects of perthamide B. The structure was elucidated by spectroscopic methods.