DIFFERENCES IN SERUM INTERLEUKIN-6 (IL-6) BETWEEN HEALTHY DEXTRAL ANDNON-DEXTRAL SUBJECTS

Serum interleukin-6 (IL-6) was measured in picograms/ml (pg/ml) using an immunoassay (ELISA) in healthy individuals (n = 148), of whom 128 w ere classified as dextral and 20 as non-dextral, as per a laterality q uestionnaire. Only 3 (15%) non-dextral individuals had serum IL-6 leve ls above the lower limit of the assay sensitivity as compared to 59 (4 6%) of dextral individuals (P < 0.013). There were no significant corr elations between previously determined mitogen stimulated interleukin- 2 production and autoantibodies in a subset of the same individuals. W hile this data does not provide casual information, it adds to the evi dence of the asymmetric regulation of immune functions by the cerebral hemispheres.