IMMUNORESTORATIVE EFFECT OF GLUCAN IMMUNOMODULATOR ON GUINEA-PIGS WITH EXPERIMENTAL ASCARIOSIS

The immunorestorative effect of glucan immunomodulator, combined with porcine immunoglobulin and zinc (GI) on T- and B-lymphocytes and perit oneal macrophage phagocytic ability was studied in guinea pigs with ex perimental ascariosis (Ascaris suum) after a cyclophosphamide (CY)-evo ked immunosuppression. During the migration phase of A. suum infection GI exerted a significant restorative effect on the CY-reduced percent age occurrence of T- and B-cell populations in the mesenteric, mediast inal and hepatic lymph nodes and spleen of A. suum hosts. On the contr ary, it did not influence the CY-suppressed phagocytic activity and in dex of phagocytic activity of the peritoneal macrophages. The protecti ve effect of the GI evaluated by the reduction in the number of migrat ing ascarid larvae in the lungs of guinea pigs after immunosuppression with CY and administration of GI was 14.46% higher, compared with the suppressed and infected group without administration of GI.