SEQUENCE OF A PUTATIVE TRANSPORTER FROM RABBIT KIDNEY RELATED TO THE NA+ GLUCOSE COTRANSPORTER GENE FAMILY/

A 2 kb cDNA, RK-D, was isolated from a rabbit renal library by hybridi zation with the Na+/glucose cotransporter (SGLT1) cDNA. The mRNA for R K-D is also approximately 2 kb and is found predominantly in kidney. T he RK-D cDNA encodes a protein of 597 amino acids related in sequence to the SGLT family of sodium-coupled transporters, all of which are re lated to the Na+/glucose cotransporter, SGLT1. Because of the high seq uence similarity and conservation of 'signature' family features, it i s very likely that RK-D encodes a Na+-dependent cotransporter.