T. Fest et al., SUCCESSFUL RESPONSE TO ALPHA-INTERFERON 2B IN A REFRACTORY IGM AUTOAGGLUTININ-MEDIATED HEMOLYTIC-ANEMIA, Annals of hematology, 69(3), 1994, pp. 147-149
We describe the beneficial effect of recombinant alpha 2b interferon i
n a woman with an idiopathic and refractory IgM-mediated autoimmune he
molytic anemia due to low-titer, high-thermal-amplitude cold agglutini
ns. The response was partial but sustained, 2 months after interruptio
n of interferon, with hemoglobin concentrations ranging between 8.5 an
d 10 g/dl. In the literature, such rarely encountered hemolyzing warm-
reacting agglutinins are described as causing severe hemolysis with a
frequently fatal clinical outcome.