Background. A large cross-sectional study provided an opportunity to e
stimate the prevalence of childhood asthma in several regions across C
anada. Methods. In 1988, approximately 18 000 questionnaires were dist
ributed to the families of 5-8 year old children in 30 communities fro
m the following six regions across Canada: the interior of British Col
umbia, southeastern Saskatchewan, southwestern Ontario, the central re
gion of Ontario, southern Quebec, and the Maritimes (Nova Scotia and P
rince Edward island). These communities were free of point-source air
pollutants and selected to represent a range of ambient sulphate conce
ntrations. In ail 14 948 questionnaires were returned representing an
83% response rate. Results. Currently present, physician-diagnosed ast
hma was reported for 4.7% of children by their parents. Persistent whe
ezing was reported for 13% and persistent cough for 5.9%. Asthma was m
ost common in the two Maritime provinces (7.4%), and least common in B
ritish Columbia (3.3%) and Quebec (3.4%). Similar regional differences
were seen for persistent cough, persistent wheeze, and also hospital
separation rates for asthma which were approximately 800 per 100 000 f
or the Maritimes and 396 per 100 000 for British Columbia. Differences
persisted despite adjustments for several host and environmental (ind
oor and outdoor) characteristics. Conclusions. The east coast of Canad
a may be an endemic area of asthma in Canada. It confirmed by objectiv
e measures of asthma, a detailed aetiologic investigation could enhanc
e understanding of this phenomenon and the major environmental determi
nants of asthma morbidity in general.