HYPOPHYSEAL HORMONES IN YOUNG FEMALES WIT H BREAST-CANCER

Hypophyseal hormones were studied in comparison with cellular and humo ral immunity in young and middle aged females with breast cancer and c ontrols matched by age. No correlation existed between LH concentratio ns and cellular, humoral immunological parameters in young breast canc er patients. Basal secretion of FSH directly correlated with the activ ation markers expression (antigens CD30, CD38) only in young patients. Prolactin concentration was negatively related to B-cell marker (mu-c hain IgM) and expression of adhesion molecules (antigen CD11b) in the young, while in the middle-aged to mature T-cell levels only (antigen CD3). No age-specific correlations were found between immunological pa rameters and ACTH basal secretion, except direct relationship with CD 11b-positive cells expression in middle-aged subjects.