During the fetal to neonatal transition, the newborn calf encounters s
evere thermolysis due to an abrupt change in thermal environment that
is compounded by evaporation of fetal fluids and severe weather condit
ions. Maintenance of homeothermy during the neonatal period necessitat
es an acute and sustained thermogenic response by the newborn calf. It
is now widely accepted that this thermogenic response is derived from
both shivering thermogenesis in muscle tissue and nonshivering therom
genesis in brown adipose tissue (BAT). It is critical that newborn cal
ves possess functional BAT during the neonatal period. This article fo
cuses on the pre- and postnatal factors that influence nonshivering th
ermogenesis of BAT in the neonatal calf.