Loss of appetite, regardless of cause, is a significant symptom that m
ay cause extreme weight loss in older patients. The consequences of an
orexia include muscle wasting, weakness, depression, increased suscept
ibility to disease complications, and decreased immunocompetence. In t
he older population, the major causes of anorexia are pulmonary and ca
rdiac diseases, cancer, dementia, alcoholism, depression, and medicati
ons. The diagnosis is based on the physical exam, a history of weight
loss, and a review of dietary intake. Treatment strategies include man
aging GI disturbances, encouraging physical activity and socialization
, reducing fatigue and food aversions, and adding high-calorie supplem
ents of the diet.