DNA-DAMAGE CAUSED BY ANTIBIOTIC DRUGS - QUINOLONES

In the present investigation, the genotoxic potencies (SOSIP) of 10 an tibiotic quinolones (topoisomerase LT inhibitors) were tested in the s fiA::lacZ fusion containing strain Escherichia coli PQ37 using a modif ied procedure of the SOS chromotest. A number of quinolones exhibited extremely high DNA damaging effects in the absence of an exogenous met abolizing system. The highest SOS inducing potencies (SOSIP) exhibited sparfloxacin with 2,400 Delta IF/nmole, ciprofloxacin (SOSIP = 184 De lta IF/nmole) and norfloxacin (SOSIP=120 Delta IF/nmole), whereas pipe mic acid (SOSIP=4.6 Delta IF/nmole), cinoxacin (SOSIP=0.5 Delta IF/nmo le) and nalidixic acid (SOSIP=0.5 Delta IF/nmole) showed only weak gen otoxicity. The possibility of mutagenic effects caused by quinolones i n eukaryotic cells is discussed.