SYNTHESIS OF THE PENTACYCLIC INTERMEDIATE FOR DYNEMICIN-A AND UNUSUALFORMATION OF SPIRO-OXINDOLE RING

Authors
OKITA T ISOBE M
Citation
T. Okita et M. Isobe, SYNTHESIS OF THE PENTACYCLIC INTERMEDIATE FOR DYNEMICIN-A AND UNUSUALFORMATION OF SPIRO-OXINDOLE RING, Tetrahedron, 50(38), 1994, pp. 11143-11152
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
38
Year of publication
1994
Pages
11143 - 11152
Database
ISI
SICI code
0040-4020(1994)50:38<11143:SOTPIF>2.0.ZU;2-S
Abstract
A pentacyclic compound was synthesized as an important intermediate of antitumor antibiotic dynemicins. The key step was the intramolecular Heck reaction using catalytic Pd reagent. During the course of the syn thetic studies, an unusual spiro ring compound was found to be produce d via intramolecular conjugate addition.