ENDOTHELIN-A RECEPTORS MEDIATE CONTRACTION IN HUMAN CEREBRAL, MENINGEAL AND TEMPORAL ARTERIES

Authors
ADNER M JANSEN I EDVINSSON L
Citation
M. Adner et al., ENDOTHELIN-A RECEPTORS MEDIATE CONTRACTION IN HUMAN CEREBRAL, MENINGEAL AND TEMPORAL ARTERIES, Journal of the autonomic nervous system, 49, 1994, pp. 190000117-190000121
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Journal of the autonomic nervous system → ACNP
ISSN journal
01651838
Volume
49
Year of publication
1994
Supplement
S
Pages
190000117 - 190000121
Database
ISI
SICI code
0165-1838(1994)49:<190000117:ERMCIH>2.0.ZU;2-O
Abstract
Endothelin-1 (ET-1), an endothelium-derived vasoconstrictor peptide, p roduced strong contractions in human cerebral, meningeal and temporal arteries. The isopeptides ET-2 and ET-3 also showed potent constrictor activity; however, ET-3 was less potent. The selective ET(A) receptor antagonist FR 139317 mediated a shift to the right of the concentrati on-response curve of ET-1. These results suggest that the powerful con striction elicited by the endothelin-isopeptides in cerebral, meningea l and temporal arteries is mediated through ET(A) receptors.