LEVELS OF STEM-CELL FACTOR AND INTERLEUKIN-3 IN SERUM IN ACUTE PLASMODIUM-FALCIPARUM MALARIA

Authors
BURGMANN H LOOAREESUWAN S WIESINGER EC WINTER W GRANINGER W
Citation
H. Burgmann et al., LEVELS OF STEM-CELL FACTOR AND INTERLEUKIN-3 IN SERUM IN ACUTE PLASMODIUM-FALCIPARUM MALARIA, Clinical and diagnostic laboratory immunology, 4(2), 1997, pp. 226-228
Citations number
10
Categorie Soggetti
Immunology,"Infectious Diseases","Medical Laboratory Technology",Microbiology
Journal title
Clinical and diagnostic laboratory immunology → ACNP
ISSN journal
1071412X
Volume
4
Issue
2
Year of publication
1997
Pages
226 - 228
Database
ISI
SICI code
1071-412X(1997)4:2<226:LOSFAI>2.0.ZU;2-8
Abstract
The purpose of the present study was to measure serum concentrations o f stem cell factor (SCF) and interleukin-3 (IL-3) in patients with acu te Plasmodium falciparum malaria. Serum samples from 15 patients were taken on day of admission and days 7, 14, 21, and 28. Anemia developed in 80% of patients. A transient increase in IL-3 could be observed at the beginning of the disease. It remains controversial whether the me asured concentrations of IL-3 and SCF correlate with the grade of anem ia. The possibly suppressed IL-3 and SCF production may contribute to the prolonged anemia in P. falciparum malaria, as has been shown for e rythropoietin.