SPONTANEOUS ACETYLCHOLINE-RELEASE IN THE HIPPOCAMPUS EXHIBITS A DIURNAL-VARIATION IN BOTH YOUNG AND OLD RATS

Authors
MIZUNO T ARITA J KIMURA F
Citation
T. Mizuno et al., SPONTANEOUS ACETYLCHOLINE-RELEASE IN THE HIPPOCAMPUS EXHIBITS A DIURNAL-VARIATION IN BOTH YOUNG AND OLD RATS, Neuroscience letters, 178(2), 1994, pp. 271-274
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
178
Issue
2
Year of publication
1994
Pages
271 - 274
Database
ISI
SICI code
0304-3940(1994)178:2<271:SAITHE>2.0.ZU;2-1
Abstract
Extracellular levels of acetylcholine (ACh) in the hippocampus were me asured by the microdialysis method in freely moving young (3-4 months old) and old (18-24 months old) female rats over a period of 24 h to e xamine the effect of aging on hippocampal ACh release. Hippocampal ACh release during a 24-h period exhibited a diurnal variation with highe r levels during the dark cycle than during the light cycle in old rats as well as young rats. The present study suggests that a diurnal vari ation in ACh release is maintained fairly well until the rats are at l east 24 months old.