EFFECTS OF RAW SOYA DIET AND CHOLECYSTOKININ RECEPTOR BLOCKADE ON PANCREATIC GROWTH AND TUMOR INITIATION IN THE HAMSTER

Raw soya diet in the hamster had short-term trophic effects on the pan creas, causing significant increases in pancreatic weight, DNA, RNA, a nd protein. These changes appear to be mediated by cholecystokinin (CC K) because the increases were blocked by infusion of the CCKA receptor antagonist, MK329. Raw soya diet significantly increased plasma level s of CCK in both the short-term and long-term studies. However, raw so ya did not potentiate pancreatic cancer in hamsters treated with N-nit rosobis(2-oxopropyl)amine (BOP). Infusion of MK329 during the initiati on period of carcinogenesis did not change tumor incidence or yield, s uggesting that endogenous CCK does not influence tumor induction durin g the initiation period in the hamster.