EFFECTS OF RAW SOYA DIET AND CHOLECYSTOKININ RECEPTOR BLOCKADE ON PANCREATIC GROWTH AND TUMOR INITIATION IN THE HAMSTER

Citation
Mk. Herrington et al., EFFECTS OF RAW SOYA DIET AND CHOLECYSTOKININ RECEPTOR BLOCKADE ON PANCREATIC GROWTH AND TUMOR INITIATION IN THE HAMSTER, Cancer letters, 82(1), 1994, pp. 7-16
Citations number
45
Categorie Soggetti
Oncology
Journal title
ISSN journal
03043835
Volume
82
Issue
1
Year of publication
1994
Pages
7 - 16
Database
ISI
SICI code
0304-3835(1994)82:1<7:EORSDA>2.0.ZU;2-N
Abstract
Raw soya diet in the hamster had short-term trophic effects on the pan creas, causing significant increases in pancreatic weight, DNA, RNA, a nd protein. These changes appear to be mediated by cholecystokinin (CC K) because the increases were blocked by infusion of the CCKA receptor antagonist, MK329. Raw soya diet significantly increased plasma level s of CCK in both the short-term and long-term studies. However, raw so ya did not potentiate pancreatic cancer in hamsters treated with N-nit rosobis(2-oxopropyl)amine (BOP). Infusion of MK329 during the initiati on period of carcinogenesis did not change tumor incidence or yield, s uggesting that endogenous CCK does not influence tumor induction durin g the initiation period in the hamster.