Mk. Herrington et al., EFFECTS OF RAW SOYA DIET AND CHOLECYSTOKININ RECEPTOR BLOCKADE ON PANCREATIC GROWTH AND TUMOR INITIATION IN THE HAMSTER, Cancer letters, 82(1), 1994, pp. 7-16
Raw soya diet in the hamster had short-term trophic effects on the pan
creas, causing significant increases in pancreatic weight, DNA, RNA, a
nd protein. These changes appear to be mediated by cholecystokinin (CC
K) because the increases were blocked by infusion of the CCKA receptor
antagonist, MK329. Raw soya diet significantly increased plasma level
s of CCK in both the short-term and long-term studies. However, raw so
ya did not potentiate pancreatic cancer in hamsters treated with N-nit
rosobis(2-oxopropyl)amine (BOP). Infusion of MK329 during the initiati
on period of carcinogenesis did not change tumor incidence or yield, s
uggesting that endogenous CCK does not influence tumor induction durin
g the initiation period in the hamster.