ANTITUMOR-ACTIVITY OF BACTERIA AND BACTERIAL PRODUCTS - ENHANCEMENT OF THE TUMOR-PROTECTIVE EFFECT OF BACTERIA BY LIPOTEICHOIC ACID

The ability of some microbial agents and/or their products to affect l ocal tumor growth was assessed in the D-12 DA rat ascites tumor model. Various bacteria and bacterial products markedly enhanced tumor resis tance when injected i.p. several days before tumor cell challenge. The tumor-protective effect of these compounds was amplified further by l ipoteichoic acid (LTA) inoculated i.p. a few days after tumor cell cha llenge. Under these conditions, the majority of animals did not exhibi t progressive tumor growth.