METHENAMINE-SILVER STAINING - A SIMPLE AND SENSITIVE STAINING METHOD FOR SENILE PLAQUES AND NEUROFIBRILLARY TANGLES

Authors
HAGA C IKEDA K IWABUCHI K AKIYAMA H KONDOH H KOSAKA K
Citation
C. Haga et al., METHENAMINE-SILVER STAINING - A SIMPLE AND SENSITIVE STAINING METHOD FOR SENILE PLAQUES AND NEUROFIBRILLARY TANGLES, Biotechnic & histochemistry, 69(5), 1994, pp. 295-300
Citations number
16
Categorie Soggetti
Cytology & Histology","Biothechnology & Applied Migrobiology
Journal title
Biotechnic & histochemistry → ACNP
ISSN journal
10520295
Volume
69
Issue
5
Year of publication
1994
Pages
295 - 300
Database
ISI
SICI code
1052-0295(1994)69:5<295:MS-ASA>2.0.ZU;2-7
Abstract
An improved methenamine-silver impregnation method is presented which exhibits sensitivity for amyloid substances comparable to that of anti -beta protein immunostaining. In optimally treated sections, this tech nique stained both beta-amyloid deposits and neurofibrillary tangles, which are known to have a beta-pleated structure. This simple procedur e allows a large number of sections to be stained for routine examinat ion.