ALLOGENEIC MARROW TRANSPLANTATION FOR MYELODYSPLASTIC SYNDROME COMPLICATING AUTOLOGOUS BONE-MARROW TRANSPLANTATION

A patient with refractory relapsed Hodgkin's disease underwent an auto logous bone marrow transplant in July 1987 and achieved remission of H odgkin's disease. He had complete hematological recovery but developed pancytopenia 3 years post bone marrow transplantation with morphologi cal evidence of myelodysplasia. High-dose cyclophosphamide, 200 mg/kg, chemotherapy followed by an allogeneic bone marrow transplant from a HLA-matched sibling was performed in April 1991 with complete hematolo gical recovery. Allogeneic bone marrow transplantation was thus used s uccessfully to treat a potential complication of autologous bone marro w transplantation.