GROWTH PROMOTION BY HOMOCYSTEINE THIOLACTONE AND ITS ALPHA-ALKYLATED DERIVATIVE - A ROLE FOR EXCESS GROWTH IN HOMOCYSTINURIAS

Authors
LUBEC B SZEKERES T
Citation
B. Lubec et T. Szekeres, GROWTH PROMOTION BY HOMOCYSTEINE THIOLACTONE AND ITS ALPHA-ALKYLATED DERIVATIVE - A ROLE FOR EXCESS GROWTH IN HOMOCYSTINURIAS, Amino acids, 7(1), 1994, pp. 109-112
Citations number
6
Categorie Soggetti
Biology
Journal title
Amino acids → ACNP
ISSN journal
09394451
Volume
7
Issue
1
Year of publication
1994
Pages
109 - 112
Database
ISI
SICI code
0939-4451(1994)7:1<109:GPBHTA>2.0.ZU;2-2
Abstract
It is controversial whether homocysteic acid or other homocysteine der ivatives show growth promoting effects. In a clonogenic assay we could show that homocysteine thiolactone and its alpha alkylated derivative increased colony formation significantly. Our work favorites previous observations showing growth promoting activity of homocysteine deriva tives and encourages further studies on that subject with implications for growth in physioogy and under pathological conditions.