The authors studied the incidence of atlanto-axial joint involvement b
y conventional radiography and CT in 183 patients with classical or de
finite rheumatoid arthritis (RA). In determining lesions the significa
nce of factors such as age, sex, duration and severity of the disease
was evaluated. Atlanto-axial subluxations turned out to be quite frequ
ent (30%) in the series of patients examined and were directly correla
ted with age, duration and stage of the disease, and extra-articular m
anifestations. Clinical symptoms were evident in only 70.9% of cases,
confirming the correlation reported by other authors between clinical
manifestations and radiologically observed lesions. Traditional radiog
raphy performed in the dynamic position revealed a prevalence of anter
ior subluxation, whereas CT gave a precise indication of the entity an
d type of atlanto-axial lesion. In conclusion, the authors confirm the
importance of such investigations in all patients with RA, even those
without evident clinical manifestations. They also emphasize the nece
ssity of periodic monitoring in view of the possible risk of mortality
in these patients.