Aa. Borg et al., COMBINATION THERAPY FOR RHEUMATOID-ARTHRITIS AND DRUG-INDUCED SYSTEMIC LUPUS-ERYTHEMATOSUS, Clinical rheumatology, 13(3), 1994, pp. 522-524
Development of drug-induced systemic lupus erythematosus (SLE) is an u
ncommon complication of the use of D-penicillamine and sulphasalazine.
We report two cases of patients with rheumatoid arthritis (RA) who de
veloped symptoms and signs of SLE and suggest that increasing use of t
hese two agents as combination therapy in RA may cause an additive ris
k to the occurrence of this complication.