Rk. Avery, INFECTIONS AND IMMUNIZATIONS IN ORGAN TRANSPLANT RECIPIENTS - A PREVENTIVE APPROACH, Cleveland Clinic journal of medicine, 61(5), 1994, pp. 386-392
Immunization remains a cornerstone of preventive practice, but the sub
optimal response to vaccinations in patients receiving immunosuppressi
ve therapy presents an ongoing challenge. More work is needed to deter
mine which of the numerous strategies for preventing symptomatic cytom
egalovirus infection is most effective and economical, and under which
circumstances. Prevention of Pneumocystis carinii pneumonia remains a
n important issue, especially in sulfa-intolerant patients. The relati
onship between different immunosuppressive programs and occurrence of
infectious complications such as lymphoproliferative disease is just b
eginning to be understood. The toxicity of amphotericin B in this popu
lation has led to a search for more effective means of preventing and
treating fungal infections. Finally, a new set of possible pathogens (
such as the recently recognized human herpesvirus-6) is on the horizon
.