SCLERODERMA RENAL CRISIS AS A POSSIBLE COMPLICATION OF CYCLOSPORINE-AWITHDRAWAL

The pharmacological treatment of systemic sclerosis (SSc) has been dis couraging. In view of this, therapeutic trials with cyclosporine A (Cy A) are outstanding particularly in patients with a rapid cutaneous inv olvement. We report the case of a patient whose SSc cutaneous manifest ations dramatically improved with CyA therapy. Its subsequent withdraw al led to a quick onset of a fatal sclerodermal renal crisis. We belie ve that in our patient there could have been a cause and effect relati onship between the suspension of CyA and kidney sclerodermal complicat ion.