SEQUENCE AND STRUCTURE SIMILARITIES OF CATHEPSIN-B FROM THE PARASITE SCHISTOSOMA-MANSONI AND HUMAN LIVER

Authors
KLINKERT MQ CIOLI D SHAW E TURK V BODE W BUTLER R
Citation
Mq. Klinkert et al., SEQUENCE AND STRUCTURE SIMILARITIES OF CATHEPSIN-B FROM THE PARASITE SCHISTOSOMA-MANSONI AND HUMAN LIVER, FEBS letters, 351(3), 1994, pp. 397-400
Citations number
14
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
351
Issue
3
Year of publication
1994
Pages
397 - 400
Database
ISI
SICI code
0014-5793(1994)351:3<397:SASSOC>2.0.ZU;2-H
Abstract
A three-dimensional structure of Schistosoma mansoni cathepsin B was m odelled using the coordinates of the crystal Structure of the human li ver enzyme. Both enzymes appear to share remarkable structural similar ity. However, an examination of the models complexed with two syntheti c inhibitors revealed differences in inhibitor binding, as confirmed b y differences in the 50% inhibitory concentration of the same inhibito r.