AN ANTIFUNGAL GAMMA-PYRONE AND XANTHONES WITH MONOAMINE-OXIDASE INHIBITORY ACTIVITY FROM HYPERICUM BRASILIENSE

Citation
L. Rocha et al., AN ANTIFUNGAL GAMMA-PYRONE AND XANTHONES WITH MONOAMINE-OXIDASE INHIBITORY ACTIVITY FROM HYPERICUM BRASILIENSE, Phytochemistry, 36(6), 1994, pp. 1381-1385
Citations number
30
Categorie Soggetti
Plant Sciences
Journal title
ISSN journal
00319422
Volume
36
Issue
6
Year of publication
1994
Pages
1381 - 1385
Database
ISI
SICI code
0031-9422(1994)36:6<1381:AAGAXW>2.0.ZU;2-T
Abstract
A new gamma-pyrone (hyperbrasilone), three known xanthones (1,5-dihydr oxyxanthone, 5-hydroxy-1-methoxyxanthone and 6-deoxyjacareubin) and be tulinic acid have been isolated from a dichloromethane extract of stem s and roots of Hypericum brasiliense. Their structures were establishe d by spectroscopic methods (UV, EI-MS, H-1 and C-13 NMR) and that of t he gamma-pyrone was confirmed by X-ray crystallography. Hyperbrasilone and the xanthones were all antifungal against Cladosporium cucumerinu m, while the three xanthones showed differing degrees of inhibition of monoamine oxidase A and B.