ROTENOIDS AND CHALCONES FROM MUNDULEA-SERICEA THAT INHIBIT PHORBOL ESTER-INDUCED ORNITHINE DECARBOXYLASE ACTIVITY

Authors
LUYENGI L LEE IS MAR W FONG HHS PEZZUTO JM KINGHORN AD
Citation
L. Luyengi et al., ROTENOIDS AND CHALCONES FROM MUNDULEA-SERICEA THAT INHIBIT PHORBOL ESTER-INDUCED ORNITHINE DECARBOXYLASE ACTIVITY, Phytochemistry, 36(6), 1994, pp. 1523-1526
Citations number
13
Categorie Soggetti
Plant Sciences
Journal title
Phytochemistry → ACNP
ISSN journal
00319422
Volume
36
Issue
6
Year of publication
1994
Pages
1523 - 1526
Database
ISI
SICI code
0031-9422(1994)36:6<1523:RACFMT>2.0.ZU;2-Z
Abstract
Two novel rotenoids, (-)-13 alpha-hydroxydeguelin and (-)-13 alpha-hyd roxytephrosin, and a new chalcone, munsericin, were isolated from the bark of Mundulea sericea, and their structures were elucidated by spec troscopic methods. Also obtained were the parent rotenoids, deguelin a nd tephrosin, and the known chalcone, 4-hydroxylonchocarpin. The roten oids and chalcones exhibited potent inhibitory activity against phorbo l ester-induced ornithine decarboxylase activity in cultured mouse 308 epidermal cells.