Increasingly sophisticated neural imaging and electrophysiologic techn
iques are beginning to demonstrate abnormalities in some patients who
have the sequelae of mild head injury (MHI). Although the exact basis
of many features of postconcussive syndrome remains elusive, these new
er techniques are beginning to provide an anatomic and physiologic exp
lanation for this disorder. Study of MHI suffers from several methodol
ogic weaknesses. First, definitions vary between studies.1 The most co
mmonly used and simplest definition is a Glasgow Coma Scale (GCS) scor
e of 13 to 15. The GCS, which grades patients on a scale of 3 to 15 (u
sing a simple clinical examination), has been criticized for not measu
ring behavior. Moderate head injury (HI) is usually defined as a GCS o
f 9 to 12 on initial examination. A GCS of 8 or lower is interpreted a
s indicating severe HI. Some authors refine the definition of MHI, req
uiring loss of consciousness (LOC) of less than 20 minutes and an abse
nce of focal findings on examination in addition to a GCS of 13 to 15;
however, the older literature relies more heavily on the duration of
LOC or retrograde amnesia in defining MHI. Second, most imaging studie
s do not limit themselves to MHI. Studies are usually performed on hos
pitalized patients; those who are discharged from emergency rooms or w
ho fail to seek immediate medical attention are underrespresented. Thi
rd, the timing of the study has an influence on the findings. Studies
are obtained at various times after injury, and this variable is not a
lways analyzed.